OLIGOMETHYLENE-BRIDGED VITAMIN-B-12 DIMERS

被引：18

作者：

KRAUTLER, B

DERER, T

LIU, PL

MUHLECKER, W

PUCHBERGER, M

KRATKY, C

GRUBER, K

机构：

[1] GRAZ UNIV, INST PHYS CHEM, A-8010 GRAZ, AUSTRIA

[2] UNIV GENEVA, DEPT CHIM ORGAN, CH-1211 GENEVA, SWITZERLAND

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1995年 / 34卷 / 01期

关键词：

ALKANEDIYL-BRIDGED COMPLEXES; COBALT COMPOUNDS; VITAMIN-B-12;

D O I：

10.1002/anie.199500841

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of the highly nucleophilic CoI form of vitamin B12 with 1,ω‐dibromo‐n‐alkanes (ω ≥ 4) leads to oligomethylene‐bridged B12 dimers in high yields. Use of 1,4‐dibromobutane results in a dimer (shown schematically on the right), in which the two cobalamin moieties are tightly packed and coaxially linked through a tetramethylene chain, which is a synclinal conformation. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：84 / 86

页数：3

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