Ionizing radiation-induced apoptosis is associated with c-Jun expression and c-Jun/AP-1 activation in the developing cerebellum of the rat

被引：32

作者：

Ferrer, I ^{[1
]}

Barron, S ^{[1
]}

RodriquezFarre, E ^{[1
]}

Planas, AM ^{[1
]}

机构：

[1] CSIC,CID,DEPT FARMACOL & TOXICOL,E-08034 BARCELONA,SPAIN

来源：

NEUROSCIENCE LETTERS | 1995年 / 202卷 / 1-2期

关键词：

radiation-induced apoptosis; Jun; Fos; AP-1; developing brain;

D O I：

10.1016/0304-3940(95)12220-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have shown that ionizing radiation-induced cell death in the developing brain has morphological characteristics of apoptosis and is associated with internucleosomal DNA fragmentation. In the present study, we have observed c-Jun induction in cells sensitive to ionizing radiation during the whole process of radiation-induced cell death, and that this expression is accompanied by modifications in the composition of AP-1 complexes: c-Jun/AP-1 activity is highly increased whereas Jun D/AP-1 is slightly decreased. These results show that c-Jun expression and c-Jun/AP-1 activity are induced in the developing brain following ionizing radiation.

引用

页码：105 / 108

页数：4

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