CLONING OF 2 RABBIT GRO HOMOLOGS AND THEIR EXPRESSION IN ALVEOLAR MACROPHAGES

被引：11

作者：

JOHNSON, MC ^{[1
]}

GOODMAN, RB ^{[1
]}

KAJIKAWA, O ^{[1
]}

WONG, VA ^{[1
]}

MONGOVIN, SM ^{[1
]}

MARTIN, TR ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH MED,DEPT MED,DIV PULM & CRIT CARE MED,SEATTLE,WA 98195

来源：

GENE | 1994年 / 151卷 / 1-2期

关键词：

RABGRO; RABBIT PERMEABILITY FACTOR 2; CHEMOKINE; NEUTROPHIL CHEMOATTRACTANT;

D O I：

10.1016/0378-1119(94)90684-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We cloned two rabbit GRO homologue cDNAs from a lipopolysaccharide-stimulated rabbit alveolar macrophage (AM) cDNA library. One cDNA contains the complete coding sequence for a new mature GRO protein, RabGRO, which shares 68, 78 and 70% amino-acid identity with human GRO-alpha, -beta and -gamma, respectively, The other cDNA contains previously unreported sequence encoding a second GRO protein, rabbit permeability factor 2. The two Rab GRO proteins share 93% identity. Northern analysis shows that Rab AM GRO expression is rapidly induced by lipopolysaccharide. These findings suggest that GRO chemokines may be important in the pulmonary inflammation that occurs with septic lung injury.

引用

页码：337 / 338

页数：2

共 4 条

[1]

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[2]

GOODMAN RB, 1993, CHEST, V105, pS99

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[4] IDENTIFICATION OF A 2ND NEUTROPHIL-CHEMOATTRACTANT CYTOKINE GENERATED DURING AN INFLAMMATORY REACTION IN THE RABBIT PERITONEAL-CAVITY INVIVO - PURIFICATION, PARTIAL AMINO-ACID-SEQUENCE AND STRUCTURAL RELATIONSHIP TO MELANOMA-GROWTH-STIMULATORY ACTIVITY [J].

JOSE, PJ ;

COLLINS, PD ;

PERKINS, JA ;

BEAUBIEN, BC ;

TOTTY, NF ;

WATERFIELD, MD ;

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WILLIAMS, TJ .

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