PHARMACEUTICAL HETEROGENEOUS SYSTEMS .2. STUDY OF HYDROLYSIS OF ASPIRIN IN COMBINATION WITH FATTY ACID TABLET LUBRICANTS

被引：9

作者：

MAULDING, HV

ZOGLIO, MA

JOHNSTON, EJ

机构：

[1] Pharmacy Research and Development and Analytical Department, Sandoz Pharmaceuticals, Hanover, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 11期

关键词：

Aspirin hydrolysis—tablets; Column chromatography—separation; Fatty acids; effect—aspirin hydrolysis; GLC—analysis; UV spectrophotometry—analysis;

D O I：

10.1002/jps.2600571110

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stearic acid USP, in combination with aspirin in tablets, capsules, and powder mixes increases the rate of salicylic acid formation over pure aspirin controls. The breakdown of aspirin in combination with stearic acid USP and reagent grade stearic and palmitic acids has been studied with regard to the relative suitability of the fatty acids in question as tablet lubricants. Commercial stearic acid was found to have a marked effect on acceleration of salicylic acid formation as compared to reagent palmitic and stearic acids which were 95% + pure (gas chromatography). In powders and tablets with a constant aspirin: fatty acid ratio (20:1) the degree of aspirin degradation reaches a maximum when the two reagent acids are mixed together at approximately the same molar ratio as found in stearic acid USP. This maximum closely parallels the minimum on the melting point curve for mixtures of stearic and palmitic acids. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1873 / &

共 5 条

[1] ANALYSIS OF ACETYLSALICYLIC ACID AND ACETYLSALICYCLIC ACID TABLETS [J].