DEVELOPMENTAL AND AGING CHANGES IN THE EXPRESSION PATTERNS OF BETA-AMYLOID IN THE BRAINS OF NORMAL AND DOWN-SYNDROME CASES

被引：30

作者：

TAKASHIMA, S ^{[1
]}

KURUTA, H ^{[1
]}

MITO, T ^{[1
]}

NISHIZAWA, M ^{[1
]}

KUNISHITA, T ^{[1
]}

TABIRA, T ^{[1
]}

机构：

[1] NATL INST NEUROSCI,DIV DEMYELINATING DIS & AGING,NCNP,TOKYO,JAPAN

来源：

BRAIN & DEVELOPMENT | 1990年 / 12卷 / 04期

关键词：

aging; Alzheimer disease; amyloid; Brain development; dementia; Down syndrome;

D O I：

10.1016/S0387-7604(12)80066-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Immunohistochemical staining with polyclonal antibodies to synthetic amyloid (residues 1–28 of A4) was performed on normal and Down syndrome brains from fetuses to adults. Positive staining appeared in the cytoplasmic processes of astrocytes in the subpial layer and white matter of developing brains, and reappeared in astrocytic fibers of the subpial layer as well as in cerebrovascular and plaque core amyloid in elderly brains. The reappearance of positively stained astrocytes and amyloid occurred earlier in adult Down syndrome patients. The results indicate that the A4 protein is a developmental protein, and its reappearance in Alzheimer and adult Down syndrome brains may be related to the regeneration process. © 1990, All rights reserved.

引用

页码：367 / 371

页数：5

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