TOTAL SYNTHESIS OF (+)-HITACHIMYCIN

被引：20

作者：

SMITH, AB ^{[1
]}

RANO, TA ^{[1
]}

CHIDA, N ^{[1
]}

SULIKOWSKI, GA ^{[1
]}

机构：

[1] UNIV PENN,MONELL CHEM SENSES CTR,PHILADELPHIA,PA 19104

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 04期

关键词：

D O I：

10.1021/jo00291a005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of the macrocyclic antibiotic-antitumor agent (+)-hitachimycin (1) has been achieved via a convergent and efficient route (22 steps, 1.2% overall yield). The key transformation entailed a highly stereoselective, three-component coupling of (-)-5-methoxycyclopentenone (5) with a zincate derived from vinyl iodide 4a and aldehyde (-)-6. © 1990, American Chemical Society. All rights reserved.

引用

页码：1136 / 1138

页数：3

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