SERUM LEVEL OF 7-ALPHA-HYDROXYCHOLESTEROL IN HYPERCHOLESTEROLEMIC PATIENTS TREATED WITH CHOLESTYRAMINE

被引：12

作者：

BASCOUL, J

GOZE, C

DOMERGUE, N

DEPAULET, AC

机构：

[1] INSERM U.58, Montpellier

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1044卷 / 03期

关键词：

7α-Hydroxycholesterol; Cholestyramine; Hypercholesterolemia; Plasma;

D O I：

10.1016/0005-2760(90)90080-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Serum levels of 7α-hydroxycholesterol (7α(OH)C) were found to increase considerably in hypercholesterolemic patients treated with cholestyramine. After 3-5 days, the normal level, which is in the range of 0.04 mg/1, rose to 1 mg/l. When the treatment was stopped it decreased rapidly with a half-life analogous to that of LDLs. This phenomenon was also observed in non-hypercholesterolemic humans. More than 75% of 7α(OH)C is carried in blood by the LDLs. © 1990.

引用

页码：357 / 360

页数：4

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