THE INFLUENCE OF HYPERTHERMIA INVITRO ON THE FUNCTIONS OF PERITONEAL-MACROPHAGES IN MICE

被引：22

作者：

YOSHIOKA, H

KOGA, S

MAETA, M

SHIMIZU, N

HAMAZOE, R

MURAKAMI, A

机构：

[1] The First Department of Surgery, Tottori University School of Medicine, Yonago, 683

来源：

JAPANESE JOURNAL OF SURGERY | 1990年 / 20卷 / 01期

关键词：

hyperthermia in vitro; macrophage function; total-body hyperthermia;

D O I：

10.1007/BF02470725

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Total-body hyperthermia (TBHT) as a treatment for cancer may lead to a reduction in the host's immunocompetence as a result of the direct effects of heat on the immune system. Thus, we studied the influences of hyperthermia in vitro on the function of peritoneal macrophages from mice. Peritoneal macrophages from C3H/HeN mice were heated in vitro for 3 hr at 37, 39, 40, 41 or 42°C. After exposure to heat, the phagocytic ability of the macrophages, as well as results of the nitroblue tetrazolium (NBT) reduction test and the cytotoxity test were examined. The changes in all these parameters showed almost the same pattern: a tendency for macrophage functions to be potentiated up to 40°C, and a tendency towards inhibited functioning at temperatures above 41°C. Although augmented functions of macrophages were observed after exposure to mild hyperthermia (<40°C), the possibility of TBHT (42°C)-induced inhibition of macrophage function must be further investigated in clinical trials of TBHT therapy for cancer. © 1990 The Japan Surgical Society.

引用

页码：119 / 122

页数：4

共 13 条

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