共 1 条
- [1] BRADSHAW J, BRIT J PHARMACOLOGY
HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF RANITIDINE IN PLASMA
被引：81
作者：
CAREY, PF
MARTIN, LE
机构：
[1] Biochemical Pharmacology Department, Glaxo Group Research Ltd Ware, Herts
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY
|
1979年
/
2卷
/
09期
关键词：
D O I：
10.1080/01483917908060138
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ;
081704 ;
摘要：
Ranitidine hydrochloride is a highly potent H2 receptor antagonist of value in the treatment of peptic ulceration. A method is described for the determination of ranitidine in biological fluids. The drug is extracted from plasma prior to determination by reverse phase high performance liquid chromatography. The method is sensitive enough to determine 10ng ranitidine per ml in plasma. The h.p.l.c. method has been automated so that analysis can be carried out without attention over a 24 hour period. The automated h.p.l.c. method has been used for studying the pharmacokinetics of oral and intravenous doses of ranitidine hydrochloride administered to man. Copyright © 1979 by Marcel Dekker, Inc.
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页码：1291 / 1303
页数：13
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