6-KETO-PROSTAGLANDIN-E1 INHIBITS THE AGGREGATION OF HUMAN-PLATELETS

被引：71

作者：

WONG, PYK

MCGIFF, JC

SUN, FF

LEE, WH

机构：

[1] NEW YORK MED COLL,DEPT PHARMACOL,VALHALLA,NY 10595

[2] UPJOHN CO,DEPT PHARMACOL,KALAMAZOO,MI 48001

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 2-3期

基金：

美国国家卫生研究院;

关键词：

6-Keto-prostaglandin E[!sub]1[!/sub; Platelet aggregation; Prostacyclin; Prostaglandin E[!sub]1[!/sub;

D O I：

10.1016/0014-2999(79)90225-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

6-Keto-prostaglandin-E1 (6-keto-PGE1) was found to have a similar potency to prostacyclin (PGI2) as an inhibitior of platelet aggregation. It caused a time and concentration dependent inhibition of ADP, collagen and epinephrine induced platelet aggregation, the dose ratios for 70% inhibition by 6-keto-PGE1 partially inhibited the release of [3H]-serotonin from platelet-rich plasma induced by collagen. © 1979.

引用

页码：245 / 248

页数：4

共 10 条

[1]

ARDIE NG, 1974, BRIT J HAEMAT, V26, P331

[2] COMPARISON OF VASODEPRESSOR EFFECTS OF PROSTACYCLIN AND 6-OXO-PROSTAGLANDIN F-1-ALPHA WITH THOSE OF PROSTAGLANDIN-E2 IN RATS AND RABBITS [J].