OVARIAN STIMULATION USING HUMAN MENOPAUSAL GONADOTROPINS WITH OR WITHOUT LHRH ANALOGS IN A LONG PROTOCOL FOR INVITRO FERTILIZATION - A PROSPECTIVE RANDOMIZED COMPARISON

被引：47

作者：

ANTOINE, JM ^{[1
]}

SALATBAROUX, J ^{[1
]}

ALVAREZ, S ^{[1
]}

CORNET, D ^{[1
]}

TIBI, C ^{[1
]}

MANDELBAUM, J ^{[1
]}

PLACHOT, M ^{[1
]}

机构：

[1] HOP TENON,DEPT OBSTET & GYNAECOL & BIOL REPROD,4 RUE CHINE,F-75970 PARIS 20,FRANCE

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 05期

关键词：

In-vitro fertilization; LHRH agonists;

D O I：

10.1093/oxfordjournals.humrep.a137144

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In order to evaluate the exact role of GnRH agonists, we have undertaken a randomized prospective study comparing two groups of 90 normo-ovulatory patients, aged <38 years and with tubal infertility with no male factor. Luteinizing hormone releasing hormone analogue (DTRP6 administered in a long protocol, for at least 15 days) was associated with human menopausal gonadotrophin (HMG) induction in group I. In group II, stimulation was performed using HMG alone (three ampoules per day in general, from days 2 to 7 of the cycle). Apart from the well known results demonstrated in the literature of a reduced incidence of inadequate responses, an absence of premature luteinization and a greater number of oocytes per retrieval (8.8 ± 4.9 versus 6.8 ± 3.2, P < 0.01 in group II), this study confirms the higher pregnancy rate (21.1 versus 12.2% per cycle and 24.7 versus 17.1% per oocyte retrieval, not significant) and underlines the higher plasma progesterone levels and lower E2/P ratio in group I from D - 1 to D + 5, which could explain a better maturation of the oocytes and the endometrium. © 1990 Oxford University Press.

引用

页码：565 / 569

页数：5

共 32 条

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