PATEAMINE - A POTENT CYTOTOXIN FROM THE NEW-ZEALAND MARINE SPONGE, MYCALE SP

被引：134

作者：

NORTHCOTE, PT ^{[1
]}

BLUNT, JW ^{[1
]}

MUNRO, MHG ^{[1
]}

机构：

[1] UNIV CANTERBURY, DEPT CHEM, CHRISTCHURCH 1, NEW ZEALAND

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 44期

关键词：

MARINE NATURAL PRODUCT; MYCALE SP; CYTOTOXIN; THIAZOLE; MACROLIDE;

D O I：

10.1016/0040-4039(91)80182-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The isolation and structural characterisation of pateamine 1, a thiazole-containing macrolide with the rare dilactone functionality, is reported. Pateamine is an exceedingly potent, but possibly selective, cytotoxin (P388: IC50 0.15 ng/ml).

引用

页码：6411 / 6414

页数：4

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