THE HUMAN PSEUDOAUTOSOMAL GM-CSF RECEPTOR ALPHA-SUBUNIT GENE IS AUTOSOMAL IN MOUSE

被引：68

作者：

DISTECHE, CM

BRANNAN, CI

LARSEN, A

ADLER, DA

SCHORDERET, DF

GEARING, D

COPELAND, NG

JENKINS, NA

PARK, LS

机构：

[1] UNIV WASHINGTON,DEPT GENET,SEATTLE,WA 98195

[2] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21702

[3] IMMUNEX CORP,SEATTLE,WA 98101

来源：

NATURE GENETICS | 1992年 / 1卷 / 05期

关键词：

D O I：

10.1038/ng0892-333

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The gene encoding the granulocyte macrophage colony stimulating factor receptor alpha-subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse. By in situ hybridization and genetic mapping, Csf2ra maps at telomeric band D2 of mouse chromosome 19. This first instance of a pseudoautosomal locus in human being autosomal in mouse, indicates incomplete conservation between the human and mouse X chromosomes and suggests that the genetic content of the pseudoautosomal region may differ between species of eutherian mammals due to chromosomal rearrangements.

引用

页码：333 / 336

页数：4

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[1] INACTIVATION OF THE ZFX GENE ON THE MOUSE X-CHROMOSOME [J].