SODIUM VALPROATE ACUTELY INHIBITS LAMOTRIGINE METABOLISM

被引：207

作者：

YUEN, AWC ^{[1
]}

LAND, G ^{[1
]}

WEATHERLEY, BC ^{[1
]}

PECK, AW ^{[1
]}

机构：

[1] WELLCOME RES LABS,LANGLEY COURT,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 33卷 / 05期

关键词：

SODIUM VALPROATE; LAMOTRIGINE; INTERACTION; GLUCURONIDE FORMATION;

D O I：

10.1111/j.1365-2125.1992.tb04079.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Concomitant administration of sodium valproate (VPA) reduced lamotrigine (LTG) total clearance by approximately 21% and increased elimination half-life and AUC. Reduced elimination occurred acutely within the first hour. Renal elimination of LTG was not impaired. The most probable explanation for this effect is hepatic competition between VPA and LTG for glucuronidation. Volume of distribution and parameters related to absorption, C(max) and t(max) were unchanged.

引用

页码：511 / 513

页数：3

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