ROLE OF THE GALACTOSE LECTIN OF ENTAMOEBA-HISTOLYTICA IN ADHERENCE-DEPENDENT KILLING OF MAMMALIAN-CELLS

被引：66

作者：

SAFFER, LD

PETRI, WA

机构：

[1] UNIV VIRGINIA,MED CTR,DEPT MED,ROOM 2115 MR4 BLDG,CHARLOTTESVILLE,VA 22908

[2] UNIV VIRGINIA,MED CTR,DEPT MICROBIOL,CHARLOTTESVILLE,VA 22908

[3] UNIV VIRGINIA,MED CTR,DIV INFECT DIS,CHARLOTTESVILLE,VA 22908

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 12期

关键词：

D O I：

10.1128/IAI.59.12.4681-4683.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Entamoeba histolytica extracellular killing of host cells is contact dependent. Adherence to human colonic epithelial cells and mucins is mediated by a galactose-specific lectin. The effect on cytotoxicity of a panel of monoclonal antibodies (MAb) directed against the galactose lectin was tested. As expected, those MAb which inhibited adherence also decreased cytotoxicity. However, one antilectin MAb blocked cytotoxicity after adherence had occurred, indicating that the lectin has a role in cell killing that is distinct from its adherence function.

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页码：4681 / 4683

页数：3

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