TITANIUM-CATALYZED EPOXY HYDROXYLATION OF ALLYLIC ALCOHOLS - A CONVENIENT DIASTEREOSELECTIVE SYNTHESIS OF EPOXY DIOLS

被引：14

作者：

ADAM, W

NESTLER, B

机构：

[1] Institut für Organische Chemie, Universität Wüirzburg, D-W-8700, Am Hubland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 05期

关键词：

D O I：

10.1002/anie.199307331

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In a two-step one-pot procedure the allylic alcohol 1 can be converted diastereoselectively into the epoxy diols (S*,R*,S*)- and (S*,R*,R*)-3 (d = 95:5), simply by adding a catalytic amount of Ti(OiPr)4 to a photooxygenated solution of the allylic alcohol 1. and stopping the reaction after the complete conversion of the hydroperoxide (S*,S*)-2. which is present in addition to the R*,S* isomer. TTP = tetraphenylporphyrin. [GRAPHICS]

引用

页码：733 / 735

页数：3

共 12 条

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