TEMPORAL-ORDER OF S-PHASE AND MITOSIS IN FISSION YEAST IS DETERMINED BY THE STATE OF THE P34(CDC2) MITOTIC B-CYCLIN COMPLEX

被引：334

作者：

HAYLES, J

FISHER, D

WOOLLARD, A

NURSE, P

机构：

[1] Cell Cycle Laboratory Imperial Cancer Research Fund Lincoln's Inn Fields, London

来源：

CELL | 1994年 / 78卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0092-8674(94)90542-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We show here that the state of the p34(cdc2)-p56(cdc13) mitotic B cyclin complex determines whether a fission yeast cell undergoes S phase or mitosis. Mutants defective for p56(cdc13) reset to G1 and rereplicate their DNA, while cells completely lacking the p34(cdc2)-p56(cdc13) complex undergo multiple rounds of S phase. In contrast, formation of the p34(cdc2)-p56(cdc13) complex in G1 promotes cells inappropriately into mitosis. We propose that the temporal order of S phase and mitosis is maintained by the presence or absence of the p34(cdc2)-p56(cdc13) complex.

引用

页码：813 / 822

页数：10

共 41 条

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