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IMMUNOGENICITY OF THE ESCHERICHIA-COLI FIMBRIAL ANTIGEN K99 WHEN EXPRESSED BY SALMONELLA-ENTERITIDIS 11RX

被引：5
作者：
BERTRAM, EM
ATTRIDGE, SR
KOTLARSKI, I
机构：
[1] The Department of Microbiology and Immunology, The University of Adelaide, Adelaide
来源：
VACCINE | 1994年 / 12卷 / 15期
关键词：
SALMONELLA; K99; CD4+ AND CD8+ T CELLS;
D O I：
10.1016/0264-410X(94)90144-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Salmonella strains expressing the Escherichia coli fimbrial protein K99 were used to immunize adult mice, and the resulting anti-K99 T-cell responses were examined. Immunized animals displayed delayed-type hyper sensitivity responses when challenged with K99 in the footpad. Lymphoid cells from immunized animals proliferated and released cytokines when cultured in vitro with K99 or peptides generated by cyanogen bromide treatment; the T cells which responded had the CD4+ phenotype.
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页码：1372 / 1378
页数：7
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