EFFECTS OF THE ANTIESTROGEN TAMOXIFEN ON LOW-DENSITY-LIPOPROTEIN CONCENTRATIONS AND OXIDATION POSTMENOPAUSAL WOMEN

被引：55

作者：

GUETTA, V

LUSH, RM

FIGG, WD

WACLAWIW, MA

CANNON, RO

机构：

[1] Cardiology Branch, National Heart, Lung, Blood Institute, Bethesda, MD

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1995年 / 76卷 / 14期

关键词：

D O I：

10.1016/S0002-9149(99)80302-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The antiestrogen tamoxifen, when administered to postmenopausal women at conventional dosages, reduces low-density lipoprotein levels and protects low-density lipoproteins from oxidation, These effects may account for the reduction in cardiovascular events noted in breast cancer treatment trials.

引用

页码：1072 / &

共 5 条

[1]

McDonald, Stewart, The Scottish Breast Cancer Committee, Fatal Myocardial Infarction in the Scottish Adjuvant Tamoxifen Trial, Br Med J, 303, pp. 435-437, (1991)

[2]

Love, Wiebe, Newcomb, Cameron, Leventhal, Jordan, Feyzi, DeMets, Effects of tamoxifen on cardiovascular risk factors in postmenopausal women, Ann Intern Med, 115, pp. 860-864, (1991)

[3]

Wiseman, Paganga, Rice-Evans, Halliwell, Protective action of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoprotein: a mechanism accounting for the cardioprotective action of tamoxifen?, Biochem J, 292, pp. 635-638, (1993)

[4]

Steinberg, Parasarathy, Carew, Khoo, Witztum, Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity, N Engl J Med, 320, pp. 915-923, (1989)

[5]

Sack, Rader, Cannon, Oestrogen and inhibition of oxidation of low-density lipoprotein in postmenopausal women, Lancet, 343, pp. 269-270, (1994)

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