Ninety-two patients with migraine were reassessed at 15 to 20 years after their first attendance. Follow-up showeb that they had first had migraine from 16 to 69 years previously. In 27 patients attacks had ceased. Of 63 with continuing attacks significant improvement had occurred in 44 Neither age of patient nor age at onset of attacks, nor time since onset, was clearly associated with persistence of attacks. No consistent change in attacks occurred after the menopause in women. In the few patients observed no consistent change was noted with the development either of raised blood pressure or of cervical spondylosis. This work was supported by a grant from the Medical Research Council, to whom our thanks are due. Professor Ritchie Russell and Dr. John Spalding kindly let us review some patients under their care. Requests for reprints should be sent to Dr. C. W. M. Whitty, Department of Neurology, Radcliffe Infirmary, Oxford. © 1968, British Medical Journal Publishing Group. All rights reserved.