N-OXYGENATION OF N-ALKYL- AND N,N-DIALKYLANILINES BY RABBIT LIVER MICROSOMES

被引：36

作者：

HLAVICA, P

KIESE, M

机构：

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 06期

关键词：

D O I：

10.1016/0006-2952(69)90265-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The N-oxygenation of N-ethylaniline to the N-hydroxy derivative and of N,N-dimethylaniline to the N-oxide in rabbit liver microsomes were studied. Both oxygenating systems had a low affinity for oxygen and were not inhibited by carbon monoxide. They were not stimulated by the treatment of rabbits with phenobarbital. p-Chloromercuribenzoate, N-ethylmaleimide, and 8-hydroxyquinoline were found to affect the N-oxygenation of N-ethylaniline and of N,N-dimethylaniline differently. © 1969.

引用

页码：1501 / +

页数：1

共 32 条

[1]

APPEL W, 1965, N-S ARCH PHARMACOL, V251, P112

[2]

ARRHENIUS E, 1968, CANCER RES, V28, P264

[3] A buffer mixture for the alkaline range of hydrogen ion concentration determinations. [J].