SENSITIVITY INVITRO OF GIARDIA-INTESTINALIS TO DYADIC COMBINATIONS OF AZITHROMYCIN, DOXYCYCLINE, MEFLOQUINE, TINIDAZOLE AND FURAZOLIDONE

被引：29

作者：

CROUCH, AA ^{[1
]}

SEOW, WK ^{[1
]}

WHITMAN, LM ^{[1
]}

THONG, YH ^{[1
]}

机构：

[1] UNIV QUEENSLAND,MATER CHILDRENS HOSP,DEPT CHILD HLTH,IMMUNOBIOL LAB,BRISBANE 4101,AUSTRALIA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 84卷 / 02期

关键词：

D O I：

10.1016/0035-9203(90)90273-H

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The new macrolide antibiotic, azithromycin, produced significant growth inhibition of Giardia intestinalis at 100 μg/ml, but adherence inhibition was significant at concentrations as low as 1 μg/ml for the two strains used in these experiments. The dyadic combinations of azithromycin-furazolidone, doxycycline-mefloquine, doxycycline-tinidazole and mefloquine-tinidazole were synergistic for inhibition of adherence. These results suggest that these dyadic combinations may be worthy of consideration for chemotherapy of recalcitrant giardiasis. © 1990 Royal Society of Tropical Medicine and Hygiene.

引用

页码：246 / 248

页数：3

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