LIVE HUMAN B-CELL ACTIVATOR OPERATING IN ISOLATION OF OTHER CELLULAR INFLUENCES

被引：75

作者：

BIRD, AG ^{[1
]}

BRITTON, S ^{[1
]}

机构：

[1] DANDERYD HOSP,DEPT INFECT DIS,DANDERYD,SWEDEN

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 06期

关键词：

D O I：

10.1111/j.1365-3083.1979.tb03278.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using a reversed haemolytic plaque assay, we demonstrate that live but not inactivated Epstein‐Barr (EB) virus can induce human blood tymphocytes to polyclonal Ig (IgM and IgG) secretion in vitro. Unlike pokeweed mitogen this B‐cell‐activating effect takes place in relative absence of T cells. EB virus thus promises to be a tool for study of B cell function isolated from other cellular influences, although its mechanism of activation appears to be different from that of previously known B cell activators. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：507 / 510

页数：4

共 13 条

[1] BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
[2] BRITTON S, 1977, ESCAPE FROM IMMUNE S
[3] CELL-SURFACE MARKERS FOR HUMAN T AND B-LYMPHOCYTES
BROWN, G
GREAVES, MF
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1974, 4 (04) : 302 - 310
[4] SPONTANEOUS B-CELL ACTIVATION DUE TO LOSS OF NORMAL MOUSE SERUM SUPPRESSOR
BULLOCK, WW
MOLLER, E
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1972, 2 (06) : 514 - 517
[5] ANTIBODY FORMATION IN INFECTIOUS MONONUCLEOSIS .2. OTHER 19S ANTIBODIES AND FALSE-POSITIVE SEROLOGY
CARTER, RL
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1966, 12 (03) : 268 - +
[6] ACTIVATION OF HUMAN B-LYMPHOCYTES .1. DIRECT PLAQUE-FORMING CELL ASSAY FOR MEASUREMENT OF POLYCLONAL ACTIVATION AND ANTIGENIC-STIMULATION OF HUMAN B-LYMPHOCYTES
FAUCI, AS
PRATT, KR
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1976, 144 (03) : 674 - 684
[7] FAUCI AS, 1976, J IMMUNOL, V117, P2100
[8] GINSBURG WW, 1978, J IMMUNOL, V120, P33
[9] PLAQUE ASSAY FOR ALL CELLS SECRETING IG OF A GIVEN TYPE OR CLASS
GRONOWICZ, E
COUTINHO, A
MELCHERS, F
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1976, 6 (08) : 588 - 590
[10] T-CELL REGULATION OF IMMUNOGLOBULIN-SYNTHESIS AND PROLIFERATION IN POKEWEED (PA-1)-STIMULATED HUMAN LYMPHOCYTE-CULTURES
JANOSSY, G
GOMEZDELACONCHA, E
LUQUETTI, A
SNAJDR, MJ
WAXDAL, MJ
PLATTSMILLS, TAE
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1977, 6 (1-2) : 109 - 123

← 1 2 →