A LIGUSTILIDE DIMER FROM ANGELICA-SINENSIS

被引：36

作者：

HON, PM

LEE, CM

CHOANG, TF

CHUI, KY

WONG, HNC

机构：

[1] CHINESE UNIV HONG KONG, DEPT BIOCHEM, SHA TIN, HONG KONG

[2] CHINESE UNIV HONG KONG, CHINESE MED MAT RES CTR, SHA TIN, HONG KONG

[3] CHINESE UNIV HONG KONG, DEPT CHEM, SHA TIN, HONG KONG

来源：

PHYTOCHEMISTRY | 1990年 / 29卷 / 04期

关键词：

Angelica sinensis; calcium channel; ligustilide; n-butylidene phthalide; nitrendipine; phthalide; Umbelliferae;

D O I：

10.1016/0031-9422(90)85426-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel ligustilide dimer, E-232, was isolated from the roots of Angelica sinensis. Its structure was determined by spectroscopic methods. It inhibited 3H-nitrendipine binding to the dihydropyridine-sensitive calcium channel with an ic50 of 4 × 10-7 M. © 1990.

引用

页码：1189 / 1191

页数：3

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