THIMEROSAL HYPERPOLARIZES ARTERIAL SMOOTH MUSCLES IN AN ENDOTHELIUM-DEPENDENT MANNER

被引：15

作者：

BENY, JL ^{[1
]}

机构：

[1] UNIV GENEVA,DEPT BIOL ANIM,CH-1211 GENEVA 4,SWITZERLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 185卷 / 2-3期

关键词：

(Electrophysiology); Arachidonic acid; Coronary artery; Endothelium-dependent relaxation; Lysolecithin; Thimerosal;

D O I：

10.1016/0014-2999(90)90647-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thimerosal activates the production of endothelium-derived relaxing factor (EDRF). I examined whether thimerosal also causes the release of an endothelium-dependent hyperpolarizing factor (EDHF). Thimerosal caused an endothelium-dependent hyperpolarization of smooth muscle. This effect is unlikely to be caused by the property of thimerosal to inhibit the acyl-coenzyme A: lysolecithin acyltransferase (LAT) since neither arachidonic acid nor lysolecithin hyperpolarized the muscles. I conclude that thimerosal is not a pure activator of EDRF (nitric oxide) production, but that it also releases a distinct EDHF. © 1990.

引用

页码：235 / 238

页数：4

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