THE EFFECT OF ONDANSETRON ON GASTRIC-EMPTYING IN THE CONSCIOUS RAT

被引：13

作者：

FORSTER, ER ^{[1
]}

DOCKRAY, GJ ^{[1
]}

机构：

[1] UNIV LIVERPOOL,PHYSIOL LAB,MRC,SECRETORY CONTROL GRP,POB 147,LIVERPOOL L69 3BX,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 191卷 / 02期

基金：

英国医学研究理事会;

关键词：

5-HT[!sub]3[!/sub] receptors; Gastric emptying; Ondansetron; Protein meals;

D O I：

10.1016/0014-2999(90)94154-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The 5-HT3 receptor antagonist ondansetron (GR38032F) enhanced the action of a protein-rich solution in delaying gastric emptying in the conscious gastric fistula rat, but had no effect on the emptying of isotonic or hypertonic saline, acid or FOY-305 which delays emptying by release of cholecystokinin (CCK). The specific CCK-A antagonist (L-364,718) increased gastric emptying of protein-rich meals. L364,718 also increased emptying in the presence of ondansetron. They indicate that protein-rich meals release both CCK and 5-hydroxytryptamine which act in different ways to control gastric motility. © 1990.

引用

页码：235 / 238

页数：4

共 10 条

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[9] INCREASED GUT CHOLINERGIC ACTIVITY AND ANTAGONISM OF 5-HYDROXYTRYPTAMINE M-RECEPTORS BY BRL-24924 - POTENTIAL CLINICAL IMPORTANCE OF BRL-24924
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