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DIFFERENTIATION OF F9 EMBRYONAL CARCINOMA-CELLS INDUCED BY THE C-JUN AND ACTIVATED C-HA-RAS ONCOGENES

被引：79
作者：
YAMAGUCHIIWAI, Y
SATAKE, M
MURAKAMI, Y
SAKAI, M
MURAMATSU, M
ITO, Y
机构：
[1] KYOTO UNIV,INST VIRUS RES,DEPT VIRAL ONCOL,SAKYO KU,KYOTO 606,JAPAN
[2] UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,TOKYO 113,JAPAN
[3] HOKKAIDO UNIV,SCH MED,DEPT BIOCHEM,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 21期
关键词：
endoderm; gene regulation; retinoic acid; transcription factor AP1;
D O I：
10.1073/pnas.87.21.8670
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The activated c-Ha-ras oncogene induced AP1-site DNA-binding activity in F9 cells. This induction appeared to be due, at least in part, to the induction of c-jun transcription. Both activated c-Ha-ras and c-jun induced the differentiation of F9 cells to endoderm-like cells. Thus, AP1 appears to play a key role in the initial stage of F9 cell differentiation.
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页码：8670 / 8674
页数：5
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