VARICELLA IN HAIRLESS GUINEA-PIGS

被引：35

作者：

MYERS, MG

CONNELLY, BL

STANBERRY, LR

机构：

[1] Children's Hosp. Research Foundation, Cincinnati, OH

[2] Division of Infectious Diseases, Children's Hosp. Research Foundation, Cincinnati, OH 45229-2899, Elland and Bethesda Aves.

来源：

JOURNAL OF INFECTIOUS DISEASES | 1991年 / 163卷 / 04期

关键词：

D O I：

10.1093/infdis/163.4.746

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A high proportion of depilated newborn or euthymic congenitally hairless adult guinea pigs develop an erythematous papular exanthem during infection with varicella-zoster virus (VZV) previously cultivated in guinea pig cell culture. Virus has been demonstrated in tissues during varicella using polymerase chain reaction amplification and nucleic acid hybridization methods. The frequency of exanthem expression can be reduced by the prophylactic administration of VZV convalescent-phase guinea pig serum. This model should prove useful for further study of VZV pathogenesis as well as for testing putative antiviral compounds.

引用

页码：746 / 751

页数：6

共 16 条

[1] VARICELLA VACCINE TRIALS IN HEALTHY-CHILDREN - A SUMMARY OF COMPARATIVE AND FOLLOW-UP STUDIES [J].