ADENOSINE-A1-RECEPTORS MEDIATE THE PRESYNAPTIC INHIBITION OF CALCITONIN GENE-RELATED PEPTIDE RELEASE BY ADENOSINE IN THE RAT SPINAL-CORD

被引:52
作者
SANTICIOLI, P
DELBIANCO, E
MAGGI, CA
机构
[1] A MENARINI PHARMACEUT,DEPT PHARMACOL,VIA SETTE SANTI 3,I-50131 FLORENCE,ITALY
[2] UNIV FLORENCE,INST INTERNAL MED 4,I-50121 FLORENCE,ITALY
关键词
ADENOSINE; ANTINOCICEPTION; ADENOSINE RECEPTORS; SENSORY NEUROPEPTIDES; CAPSAICIN;
D O I
10.1016/0014-2999(93)90695-E
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Electrical field stimulation evoked a reproducible outflow of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from the dorsal half of the rat spinal cord, an effect which was abolished by prior application of capsaicin, tetrodotoxin or removal of extracellular Ca2+. Adenosine (EC50 3.2 muM) and the selective adenosine A1 receptor agonist N6-cyclohexyladenosine (EC50 8.2 nM) inhibited evoked CGRP-LI outflow, while the selective adenosine A2 receptor agonist CGS-21680 was ineffective up to 10 muM. The action of adenosine was prevented by the adenosine A1 receptor selective antagonist 8-cyclopentyl-1, 3-dipropylxanthine (30 muM), which did not affect CGRP-LI release on its own.
引用
收藏
页码:139 / 142
页数:4
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