ALVEOLAR LIQUID AND PROTEIN CLEARANCE IN ANESTHETIZED VENTILATED RATS

被引:122
作者
JAYR, C
GARAT, C
MEIGNAN, M
PITTET, JF
ZELTER, M
MATTHAY, MA
机构
[1] HOP HENRI MONDOR,INSERM,U296,DEPT NUCL MED,F-94010 CRETEIL,FRANCE
[2] HOP LA PITIE SALPETRIERE,DEPT PHYSIOL,F-75013 PARIS,FRANCE
[3] UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,DEPT MED,SAN FRANCISCO,CA 94143
[4] UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,DEPT ANESTHESIA,SAN FRANCISCO,CA 94143
关键词
ALBUMIN; AMILORIDE; ALVEOLAR EPITHELIUM; LUNG; OUABAIN; SODIUM; ALVEOLAR SOLUTE CLEARANCE; PULMONARY EDEMA;
D O I
10.1152/jappl.1994.76.6.2636
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Alveolar and lung liquid clearances were studied over 1, 4, and 6 h in intact anesthetized ventilated rats by instillation of 5% albumin solution with 1.5 mu Ci of I-125-labeled albumin (3 ml/kg into 1 lung or 6 ml/kg into both lungs). Alveolar protein clearance as measured by residual I-125-albumin in the lung over 6 h was similar to the slow rates measured in other species. Alveolar liquid clearance was estimated by the concentration of albumin in the air spaces. After 1 h, this concentration was 7.8 +/- 0.7 g/dl, which was significantly greater than the initial protein concentration of 5.3 +/- 0.2 g/dl (P < 0.05). Amiloride (10(-3) M) inhibited 45% of the basal alveolar liquid clearance, and ouabain (10(-3) M), instilled and intravenously infused (0.004 mg), inhibited 30% of the clearance. beta-Adrenergic agonist instillation increased alveolar liquid clearance to the fastest 1-h rate (48 +/- 3% of instilled volume) that we observed in any intact species. The removal of the instilled fluid from the lung (expressed as lung liquid clearance; 0.96 +/- 0.3 ml/h) was twice as fast as the rate of alveolar and lung liquid clearance reported in the isolated or in situ rat lung models. The rate of alveolar and lung liquid clearance in these intact rats was significantly faster than those in prior studies in dogs and sheep and was similar to the rates in rabbits.
引用
收藏
页码:2636 / 2642
页数:7
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