CREUTZFELDT-JAKOB DISEASE - ALTERATION IN GANGLIOSIDE SPHINGOSINE IN THE BRAIN OF A PATIENT

被引：14

作者：

TAMAI, Y

OHTANI, Y

MIURA, S

NARITA, Y

IWATA, T

KAIYA, H

NAMBA, M

机构：

[1] 2ND NATL TOKYO HOSP, DEPT PSYCHIAT, TOKYO 152, JAPAN

[2] GIFU UNIV, SCH MED, DEPT NEUROPSYCHIAT, KAKAMIGAHARA, GIFU 504, JAPAN

来源：

NEUROSCIENCE LETTERS | 1979年 / 11卷 / 01期

关键词：

D O I：

10.1016/0304-3940(79)90060-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gangliosides isolated from the brain of patients with Creutzfelt-Jakob (C-J) disease were analyzed. The ganglioside current was abnormally low, and the percentage distributions of individual gangliosides and the long-chain base compositions were abnormal. The C20-sphingosine contents of all the ganglioside fractions were low. Abnormalities in ganglioside long-chain bases in adult human brain have been reported previously only in patients with inherited metabolic disorders. These abnormalities in C-J disease seem to be closely related to the cause of the disease. © 1979.

引用

页码：81 / 86

页数：6

共 19 条

[1]

ANDO S, ANAL BIOCH

[2] ALTERED CELL-MEMBRANES IN CREUTZFELDT-JAKOB DISEASE - MICROCHEMICAL STUDIES [J].