MULTIPLE ANTIGENIC COMPONENTS OF GROUP-SPECIFIC ANTIGEN OF AVIAN LEUKOSIS-SARCOMA VIRUSES

Antigenic material was prepared from chick embryo fibroblast tissue cultures infected with avian leukosis-sarcoma viruses and from leukemic chicken plasma containing avian myeloblastosis virus. Four antigenic components were demonstrated by immunodiffusion and immunoelectrophoresis when these antigens were reacted with group-specific antibodies from tumor-bearing hamsters. At least two of the components were common not only to preparations from tissue cultures infected with each viral subgroup type, but also to the avian myeloblastosis virus preparation. Centrifugation experiments showed that the group-specific antigens were composed of both soluble" and "insoluble" components. It was also found that sodium lauryl sulfate could alter the diffusion rate and electrical charge of these antigenic components. © 1969."