KILLING OF FIBROBLASTS BY DEXAMETHASONE OR DIBUTYRYL ADENOSINE 3', 5'-MONOPHOSPHATE IS NOT A VALID TEST FOR CYSTIC-FIBROSIS

被引：12

作者：

KURZ, JB

PERKINS, JP

BUCHWALD, M

机构：

[1] UNIV TORONTO,DEPT MED GENET,TORONTO M5S 1A1,ONTARIO,CANADA

[2] HOSP SICK CHILDREN,RES INST,TORONTO M5G 1X8,ONTARIO,CANADA

来源：

SCIENCE | 1979年 / 206卷 / 4424期

关键词：

D O I：

10.1126/science.229552

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Assays based on the counting of total cells and of colony-forming cells were used to demonstrate that neither dexamethasone nor dibutyryl adenosine 3′,5′-monophosphate (cyclic AMP) kills human fibroblasts under a variety of conditions. These results contradict those of previous studies showing that dexamethasone and dibutyryl cyclic AMP kill a higher percentage of fibroblasts from normal humans than from individuals with cystic fibrosis. Copyright © 1979 AAAS.

引用

页码：1317 / 1319

页数：3

共 24 条

[1] ENHANCED DEXAMETHASONE RESISTANCE IN CYSTIC-FIBROSIS CELLS - POTENTIAL USE FOR HETEROZYGOTE DETECTION AND PRENATAL DIAGNOSIS [J].