CRYSTAL-STRUCTURE OF GALACTAN-BINDING MOUSE IMMUNOGLOBULIN J539-FAB AT 4.5-A RESOLUTION

被引：40

作者：

NAVIA, MA ^{[1
]}

SEGAL, DM ^{[1
]}

PADLAN, EA ^{[1
]}

DAVIES, DR ^{[1
]}

RAO, N ^{[1
]}

RUDIKOFF, S ^{[1
]}

POTTER, M ^{[1
]}

机构：

[1] NCI,CELL BIOL LAB,BETHESDA,MD

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 08期

关键词：

D O I：

10.1073/pnas.76.8.4071

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An electron-density map of the mouse galactan-binding immunoglobulin J539 (IgA2,κ) Fab has been calculated to a resolution of 4.5 Å by the method of heavy atom isomorphous replacement with four derivatives. The map has been interpreted with the aid of a computer program which systematically searched for the best fit between the electron density map and the known coordinates of individual immunoglobulin domains. The quaternary structure of J539 Fab at this resolution appears similar to that of another mouse immunoglobulin, IgA2, κ Fab, McPC603. The model coordinates for J539 Fab should allow us to proceed directly to a high resolution structure determination without further heavy atom isomorphous replacement.

引用

页码：4071 / 4074

页数：4

共 17 条

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