A NOVEL CLASS-II MHC MOLECULE WITH UNUSUAL TISSUE DISTRIBUTION

被引:120
作者
KARLSSON, L
SURH, CD
SPRENT, J
PETERSON, PA
机构
[1] Department of Immunology, Scrips Clinic and Research Foundation, San Diego, CA 92037
关键词
D O I
10.1038/351485a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
THE repertoire of mature class II-restricted T cells is generated through a complex process of selection whereby early T cells confront class II molecules in the thymus, especially on epithelial cells 1-3. Expression of class II molecules on such cells is prominent both in the cortex and in the medulla 4,5. We have identified a novel class II molecule, H-2O, which is expressed only in epithelial cells of the thymic medulla and in B cells. The unusual tissue distribution and the nonpolymorphic nature of H-2O suggest that its function is different from that of classical class II molecules.
引用
收藏
页码:485 / 488
页数:4
相关论文
共 23 条
  • [1] BEGTOVICH AB, 1990, J IMMUNOL, V144, P1957
  • [2] THE ROLE OF THE T-CELL RECEPTOR IN POSITIVE AND NEGATIVE SELECTION OF DEVELOPING T-CELLS
    BLACKMAN, M
    KAPPLER, J
    MARRACK, P
    [J]. SCIENCE, 1990, 248 (4961) : 1335 - 1341
  • [3] A HYPOTHETICAL MODEL OF THE FOREIGN ANTIGEN-BINDING SITE OF CLASS-II HISTOCOMPATIBILITY MOLECULES
    BROWN, JH
    JARDETZKY, T
    SAPER, MA
    SAMRAOUI, B
    BJORKMAN, PJ
    WILEY, DC
    [J]. NATURE, 1988, 332 (6167) : 845 - 850
  • [4] STRUCTURAL CHARACTERIZATION OF MURINE IA-ANTIGEN N-LINKED OLIGOSACCHARIDES AND LOCALIZATION OF SPECIFIC STRUCTURES TO 2 UNIQUE ALPHA-CHAIN GLYCOSYLATION SITES
    COWAN, EP
    CUMMINGS, RD
    LEE, DR
    SCHWARTZ, BD
    CULLEN, SE
    [J]. MOLECULAR IMMUNOLOGY, 1985, 22 (02) : 135 - 143
  • [5] HIROKAWA K, 1986, THYMUS, V8, P349
  • [6] EXTERNALLY DISPOSED PLASMA-MEMBRANE PROTEINS .1. ENZYMATIC IODINATION OF MOUSE L CELLS
    HUBBARD, AL
    COHN, ZA
    [J]. JOURNAL OF CELL BIOLOGY, 1975, 64 (02) : 438 - 460
  • [7] JONES PP, 1980, SELECTED METHODS CEL, P398
  • [8] LARHAMMAR D, 1985, J BIOL CHEM, V260, P4111
  • [9] TRANSGENIC HLA-DR-ALPHA FAITHFULLY RECONSTITUTES IE-CONTROLLED IMMUNE FUNCTIONS AND INDUCES CROSS-TOLERANCE TO E-ALPHA IN E-ALPHA-0 MUTANT MICE
    LAWRANCE, SK
    KARLSSON, L
    PRICE, J
    QUARANTA, V
    RON, Y
    SPRENT, J
    PETERSON, PA
    [J]. CELL, 1989, 58 (03) : 583 - 594
  • [10] WOUND MACROPHAGES EXPRESS TGF-ALPHA AND OTHER GROWTH-FACTORS INVIVO - ANALYSIS BY MESSENGER-RNA PHENOTYPING
    RAPPOLEE, DA
    MARK, D
    BANDA, MJ
    WERB, Z
    [J]. SCIENCE, 1988, 241 (4866) : 708 - 712