INVITRO PHOTODYNAMIC ACTIVITY OF KRYPTOCYANINE

被引：19

作者：

HARRIMAN, A ^{[1
]}

LUENGO, G ^{[1
]}

GULLIYA, KS ^{[1
]}

机构：

[1] BAYLOR UNIV,MED CTR,BAYLOR RES FDN,DALLAS,TX 75246

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1990年 / 52卷 / 04期

关键词：

D O I：

10.1111/j.1751-1097.1990.tb08674.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— –The photophysical properties of 1,1′‐diethyl‐4,4′‐carbocyanine chloride (kryptocyanine) have been measured in methanol solution and for the dye bound to human serum albumin, incorporated in neutral micelles and after incubation with leukemia cells. In all cases, it is found that formation of the triplet state of the dye occurs with low efficiency and that illumination of the dye under aerobic conditions does not produce significant yields of O2(1δg). Instead, the only efficient photoprocess involves rapid internal conversion from the first excited singlet state to the ground state, probably via isomerization of the polymethine sequence. These findings are discussed with respect to the demonstrated ability of kryptocyanine to photodestroy leukemic cells. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：735 / 740

页数：6

共 26 条

[1] DETERMINATION OF TRIPLET QUANTUM YIELDS BY LASER FLASH ABSORPTION SPECTROSCOPY [J].