STEREOCONTROLLED SYNTHESIS OF A TRIHYDROXYLATED A RING AS AN IMMEDIATE PRECURSOR TO 1-ALPHA,2-ALPHA,25-TRIHYDROXYVITAMIN-D3

被引：28

作者：

POSNER, GH

NELSON, TD

机构：

[1] Department of Chemistry, The Johns Hopkins University, Baltimore

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 14期

关键词：

D O I：

10.1021/jo00014a003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Bromo-2-pyrone (1) was coaxed into inverse-electron-demand Diels-Alder cycloaddition with dioxole 2 under sufficiently mild thermal conditions to allow isolation of functionally and stereochemically rich bicycloadduct endo-3 that was transformed into trihydroxylated A-ring allylic phosphine oxide as an immediate precursor to 1-alpha,2-alpha,25-trihydroxyvitamin D3.

引用

页码：4339 / 4341

页数：3

共 41 条

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