EFFECTS OF ANTINEOPLASTIC PHOSPHOLIPIDS ON PARAMETERS OF CELL-DIFFERENTIATION IN U937 CELLS

被引:51
作者
HOCHHUTH, C [1 ]
BERKOVIC, D [1 ]
EIBL, H [1 ]
UNGER, C [1 ]
DOENECKE, D [1 ]
机构
[1] MAX PLANCK INST BIOPHYS CHEM,INST BIOCHEM,MOLEK BIOL ABT,W-3400 GOTTINGEN,GERMANY
关键词
Antineoplastic phospholipids; cell differentiation; histone H10; U937; cells;
D O I
10.1007/BF01612994
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The proliferation of the human promonocytic leukemia cell line U937 is inhibited by several ether lipids, ether lipid analogues and by phorbol esters. An early effect of this retardation of cell growth is the induction of a basic chromosomal protein, histone H10. Northern blot analysis of H10 mRNA levels reveals an increase of the mRNA concentration within a few hours after addition of hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine. This early effect on the synthesis of a subtype of H1 proteins precedes the expression of several parameters of the monocytic differentiation of U937 cells. © 1990 Springer-Verlag.
引用
收藏
页码:459 / 466
页数:8
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