ABILITY OF HUMAN CHORIONIC-GONADOTROPIN BETA-SUBUNIT TO INHIBIT THE STEROIDOGENIC RESPONSE TO LUTROPIN

被引:16
作者
DIGHE, RR
MURALIDHAR, K
MOUDGAL, NR
机构
关键词
D O I
10.1042/bj1800573
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ability of the β-subunit of human chorionic gonadotropin to inhibit the response to was tested in the immature rat ovarian system and PMSG-primed rat ovarian system with progesterone production being used as the response. Human chorionic gonadotropin β-subunit was found to inhibit human and ovine lutropin-stimulated progesterone production. At a constant dose of lutropin, inhibition was dependent on the concentration of β-subunit. When concentration of the β-subunit was kept constant at 5.0μg/ml and the concentration of lutropin was varied, the inhibition was maximum at the saturating concentration of the native hormone. The α-subunit of the human chorionic gonadotropin did not inhibit the response to lutropin. The lutropin β-subunit ratio required to produce an inhibition of response was much lower than that required to bring about an observable inhibition of binding.
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页码:573 / 578
页数:6
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