X-RAY CONFORMATIONAL STUDY OF HYDRAZINO PEPTIDE ANALOGS

We have solved the crystal structures of nine pseudo-peptide analogues deriving from the hydrazino analogue of glycine or valine (N-beta-H-2-N-alpha-H-C-alpha-HR-CO2H, R = H or iPr) or proline (N-beta-H-2-N-alpha-C-alpha-H-CO2H) and containing the hydrazide (CO-N-beta-H-N-alpha <) or N-beta-Z-aminoamide [GRAPHICS] [CO-N-alpha(N-beta-HZ)] peptidomimetic link. This study gives access to the average geometry of these two links, to their inter- and intramolecular interaction modes, and to their influence on the conformational properties of the molecules.