Antitumor Activity of Some Prenylated Xanthones

被引：32

作者：

Castanheiro, Raquel A. P. ^{[1
]}

Silva, Artur M. S. ^{[2
,3
]}

Campos, Nair A. N. ^{[1
]}

Nascimento, Maria S. J. ^{[1
,4
]}

Pinto, Madalena M. M. ^{[1
,5
]}

机构：

[1] Univ Porto, Ctr Quim Med, Fac Farm, CEQUIMED, Rua Anibal Cunha 164, P-4050047 Porto, Portugal

[2] Univ Aveiro, Dept Quim, P-3810193 Aveiro, Portugal

[3] Univ Aveiro, QOPNA, P-3810193 Aveiro, Portugal

[4] Univ Porto, Fac Farm, Serv Microbiol, P-4050047 Porto, Portugal

[5] Univ Porto, Fac Farm, Serv Quim Organ, P-4050047 Porto, Portugal

来源：

PHARMACEUTICALS | 2009年 / 2卷 / 02期

关键词：

xanthones; prenylation; dehydrogenation; antitumor activity; NMR spectroscopy;

D O I：

10.3390/ph2020033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pyranoxanthones 6-8 were obtained by dehydrogenation of the respective dihydropyranoxanthones 3-5 with DDQ in dry dioxane. Two prenylated xanthones 10,11 were obtained from the reaction of 1-hydroxyxanthone (9) with prenyl bromide in alkaline medium, or by condensation of xanthone 9 with isoprene in the presence of orthophosphoric acid. The structural elucidation of the two new compounds 6,11, as well as an update of data for the already described prenylated derivatives 7,8,10 were accomplished by IR, UV, HRMS and NMR (H-1, C-13, HSQC and HMBC) techniques. The effect of the prenylated xanthone derivatives on the in vitro growth of human tumor cell lines MCF-7 (breast adenocarcinoma) and NCI-H460 (non-small cell lung cancer) is also reported. Compounds 10 and 11 have been found to exhibit a moderate growth inhibitory activity against the MCF-7 cell line.

引用

页码：33 / 43

页数：11

共 18 条

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