CONVENIENT METHODS FOR THE REDUCTION OF AMIDES, NITRILES, CARBOXYLIC ESTERS, ACIDS AND HYDROBORATION OF ALKENES USING NABH4/I2 SYSTEM

被引：167

作者：

PRASAD, ASB ^{[1
]}

KANTH, JVB ^{[1
]}

PERIASAMY, M ^{[1
]}

机构：

[1] UNIV HYDERABAD,SCH CHEM,HYDERABAD 500134,ANDHRA PRADESH,INDIA

来源：

TETRAHEDRON | 1992年 / 48卷 / 22期

关键词：

D O I：

10.1016/S0040-4020(01)81236-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Reaction of amides with NaBH4-I2 system in THF gives the corresponding amines in 70-76% yields. Reduction of nitriles yields the corresponding amines in 70-75% yields. The I2/NaBH4 system is useful in the hydroboration of olefins and the corresponding alcohols are obtained in 78-92% yields after H2O2/OH- oxidation. The reagent system is also useful for the reduction of carboxylic esters and acids to the corresponding alcohols in 60-90% yields.

引用

页码：4623 / 4628

页数：6

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