BIOSPECIFIC HAEMOSORBENTS BASED ON PROTEINASE-INHIBITOR .1. SYNTHESIS AND PROPERTIES

被引：31

作者：

PLATE, NA

VALUEV, LI

VALUEVA, TA

CHUPOV, VV

机构：

[1] ACAD SCI RUSSIA, INST PETROCHEM SYNTHESIS, LENINSKY PROSPECT 29, MOSCOW 117912, RUSSIA

[2] ACAD SCI RUSSIA, INST BIOCHEM, MOSCOW 117071, RUSSIA

[3] MOSCOW MV LOMONOSOV STATE UNIV, DEPT CHEM, MOSCOW 119899, RUSSIA

来源：

BIOMATERIALS | 1993年 / 14卷 / 01期

关键词：

HAEMOSORBENT; PROTEIN INHIBITOR; IMMOBILIZATION;

D O I：

10.1016/0142-9612(93)90075-D

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Sorbents for the removal of proteolytic enzymes from biological fluids were synthesized by immobilization of proteinase inhibitor, ovomucoid from duck egg white, in polymeric hydrogel matrix. The immobilization of the protein inhibitor modified by acryloyl chloride occurs during copolymerization of the unsaturated derivative of inhibitor with hydrophilic monomer and cross-linking agent. It was shown that the sorbent obtained possesses a high affinity for proteinases and is haemocompatible. The use of the haemosorbent for eliminating excess activated proteinase from blood is proposed.

引用

页码：51 / 56

页数：6

共 23 条

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