INFLUENCE OF HYPERTHYROIDISM ON SUPEROXIDE RADICAL AND HYDROGEN-PEROXIDE PRODUCTION BY RAT-LIVER SUBMITOCHONDRIAL PARTICLES

被引:84
作者
FERNANDEZ, V
VIDELA, LA
机构
[1] Departamento de Bioquímica, Facultad de Medicina, Universidad de Chile, Casilla 70086
来源
FREE RADICAL RESEARCH COMMUNICATIONS | 1993年 / 18卷 / 06期
关键词
HYPERTHYROIDISM; SUPEROXIDE RADICAL; HYDROGEN PEROXIDE; RAT LIVER SUBMITOCHONDRIAL PARTICLES; THYROID CALORIGENESIS; OXIDATIVE STRESS;
D O I
10.3109/10715769309147500
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Administration of daily doses of 0.1 mg of 3,5,3'-triiodothyronine (T3)/kg body weight for 3 consecutive days to fed rats elicited a calorigenic response in the animals, in concomitance with a 36% increase in the rate of 0(2) consumption by the liver. In these conditions, liver submitochondrial particles (SMP) from T3-treated rats exhibited marked increases in the rate of superoxide radical generation, both in the presence of NADH (142%) or succinate (152%). Furthermore, liver SMP from hyperthyroid animals released hydrogen peroxide at higher rates than those of euthyroid rats, either under basal conditions or in the succinate-supported process, both in the absence and presence of antimycin-A. It is concluded that the hyperthyroid state in the rat leads to a drastic enhancement in the capacity of liver mitochondria to produce active oxygen species, which correlates with the elevated respiratory rate observed in the intact organ.
引用
收藏
页码:329 / 335
页数:7
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