ANALYSIS OF FECAL NEUTRAL STEROLS IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：10

作者：

BARKER, GM ^{[1
]}

RADLEY, S ^{[1
]}

DAVIS, A ^{[1
]}

SETCHELL, KDR ^{[1
]}

OCONNELL, N ^{[1
]}

DONOVAN, IA ^{[1
]}

KEIGHLEY, MRB ^{[1
]}

NEOPTOLEMOS, JP ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,DUDLEY RD HOSP,DEPT SURG,BIRMINGHAM B18 7QH,ENGLAND

来源：

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 1993年 / 8卷 / 04期

关键词：

D O I：

10.1007/BF00290303

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Previous studies have suggested that patients with familial adenomatous polyposis (FAP) have increased faecal excretion of cholesterol but a reduction in cholesterol metabolites. It was consequently proposed that the degree of faecal cholesterol degradation could be used as a means of diagnosis. Developments in the extraction and analysis of faecal neutral sterols as well as the accurate means of diagnosing FAP by DNA analysis and indirect ophthalmoscopy has necessitated a re-examination of this proposal. Faecal neutral sterols were analysed in 10 patients with untreated FAP following a complete 5-day stool collection and compared with 9 healthy control subjects (including 4 siblings) closely matched for age and sex. The median [25 and 75, percentiles] stool wet weights were similar between the FAP (97.5 [69, 192] g.24 h(-1)) and the control (116 [61.5, 137] g.24 h(-1)) groups. Faecal cholesterol concentration was similar in the two groups (FAP=2.3 [1.4, 4.2]; control=3.5 [1.0, 6.0] mu mol .g(-1) dry wt) as was the concentration of total neutral sterols not including plant sterols (FAP=17.2 [13.4, 21.0]; control=18.2 [7.4, 21.6] mu mol.g(-1) dry wt). There were no significant differences in the proportions of cholesterol metabolised between the FAP (82.3 [74.2, 93.5]%) and control(72.1 [5.7, 81.3]%) groups. This study does not support the notion that faecal neutral sterol metabolism is uniquely different in patients with FAP.

引用

页码：188 / 192

页数：5

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