SIGNAL-TRANSDUCTION IN THE EARLY DROSOPHILA EMBRYO - WHEN GENETICS MEETS BIOCHEMISTRY

被引：24

作者：

PERRIMON, N ^{[1
]}

DESPLAN, C ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,HOWARD HUGHES MED INST,NEW YORK,NY 10021

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 11期

关键词：

D O I：

10.1016/0968-0004(94)90140-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An elegant combination of genetic and biochemical approaches has been used to investigate a variety of signal transduction pathways in developmental processes. Here, we describe the 'terminal' signaling system in the Drosophila embryo, which is responsible for pattern formation in the polar regions of the embryo. This pathway involves a membrane-bound receptor tyrosine kinase (RTK) that is similar to other Drosophila RTKs, such as sevenless, and the mammalian RTKs, such as the epidermal growth factor or platelet-derived growth factor receptors.

引用

页码：509 / 513

页数：5

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