PDGF IS ASSOCIATED WITH NEURONAL AND GLIAL ALTERATIONS OF ALZHEIMERS-DISEASE

被引：35

作者：

MASLIAH, E

MALLORY, M

ALFORD, M

DETERESA, R

SAITOH, T

机构：

[1] University of California., San Diego, School of Medicine, Department of Neurosciences, La Jolla

来源：

NEUROBIOLOGY OF AGING | 1995年 / 16卷 / 04期

关键词：

PLATELET-DERIVED GROWTH FACTOR; ALZHEIMERS DISEASE; NEUROFIBRILLARY TANGLES; NEURITIC PLAQUES; SPROUTING;

D O I：

10.1016/0197-4580(95)00050-O

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In the present study we observed that while platelet-derived growth factor (PDGF)-BB is exclusively expressed by neurons in the human brain, PDGF-AA is expressed in neurons and blood vessels. In Alzheimer's disease (AD), antibodies against PDGF-BB (but not PDGF-AA) recognized the neurofibrillary alterations of this disease. The levels of PDGF-BB correlated with the patterns of synaptic loss and sprouting while PDGF-AA immunostaining of the vessels was correlated with glial proliferation. Immunostaining was completely abolished when the antibodies were preincubated with their respective purified recombinant PDGF. Western blot analysis showed that antibodies against PDGF recognized a 31 kDa protein that was mildly increased in AD. These data suggest that PDGF, as well as other neurotrophic factors, play an important role in the mechanisms of neurofibrillary pathology in AD.

引用

页码：549 / 556

页数：8

共 49 条

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