STRUCTURE-ACTIVITY OF TOPOISOMERASE-I POISONS RELATED TO HOECHST-33342

被引：54

作者：

SUN, Q

GATTO, B

YU, CA

LIU, A

LIU, LF

LAVOIE, EJ

机构：

[1] RUTGERS STATE UNIV,COLL PHARM,DEPT PHARMACEUT CHEM,PISCATAWAY,NJ 08855

[2] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT PHARMACOL,PISCATAWAY,NJ 08855

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(01)80831-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of bisbenzimidazoles related to Hoechst 33342 were synthesized. Data on the relative activity of these bisbenzimidazoles as topoisomerase I poisons suggest that considerable flexibility exists in the location of the tertiary alkylamine moiety. With the exception of arylamine analogs, cytotoxicity was generally consistent with their relative potency as topoisomerase I poisons.

引用

页码：2871 / 2876

页数：6

共 16 条

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