STRUCTURE-ACTIVITY OF TOPOISOMERASE-I POISONS RELATED TO HOECHST-33342

被引:54
作者
SUN, Q
GATTO, B
YU, CA
LIU, A
LIU, LF
LAVOIE, EJ
机构
[1] RUTGERS STATE UNIV,COLL PHARM,DEPT PHARMACEUT CHEM,PISCATAWAY,NJ 08855
[2] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT PHARMACOL,PISCATAWAY,NJ 08855
关键词
D O I
10.1016/S0960-894X(01)80831-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of bisbenzimidazoles related to Hoechst 33342 were synthesized. Data on the relative activity of these bisbenzimidazoles as topoisomerase I poisons suggest that considerable flexibility exists in the location of the tertiary alkylamine moiety. With the exception of arylamine analogs, cytotoxicity was generally consistent with their relative potency as topoisomerase I poisons.
引用
收藏
页码:2871 / 2876
页数:6
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