INTERRELATIONSHIPS BETWEEN PLASMA HOMOVANILLIC-ACID AND INDEXES OF DOPAMINE TURNOVER IN MULTIPLE BRAIN-AREAS DURING HALOPERIDOL AND SALINE ADMINISTRATION

被引：6

作者：

CSERNANSKY, JG ^{[1
]}

BARNES, DE ^{[1
]}

BELLOWS, EP ^{[1
]}

LOMBROZO, L ^{[1
]}

机构：

[1] VET ADM MED CTR,PALO ALTO,CA 94304

来源：

LIFE SCIENCES | 1990年 / 46卷 / 10期

关键词：

D O I：

10.1016/0024-3205(90)90076-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Haloperidol or saline was administered to rats daily for 1, 8, 15 or 22 days. During haloperidol, but not saline administration, changes in plasma homovanillic acid (HVA) concentrations were correlated with changes in nucleus accumbens HVA. Haloperidol administration also had a significant effect on the intercorrelation of dopamine (DA) concentrations and indices of DA turnover across multiple brain areas. In particular, intercorrelations of HVA concentrations among DA terminal brain areas (i.e. striatum, nucleus accumbens, and olfactory tubercle) occurred only during haloperidol treatment. © 1990.

引用

页码：707 / 713

页数：7

共 14 条

[1] EFFECTS OF HALOPERIDOL AND PROBENECID ON PLASMA AND CSF DOPAMINE METABOLITES IN RHESUS-MONKEY (MACACCA-MULATTA) [J].