STRUCTURE OF MOUSE VASOPRESSIN AND OXYTOCIN GENES

被引：99

作者：

HARA, Y

BATTEY, J

GAINER, H

机构：

[1] Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD

来源：

MOLECULAR BRAIN RESEARCH | 1990年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Oxytocin; Vasopressin;

D O I：

10.1016/0169-328X(90)90045-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mouse vasopressin (VP) and oxytocin (OT) genes were isolated from a genomic library and the nucleotide sequences of the two genes were determined. The two genes have similar three exon structures and a high similarity in the part of exon 1 encoding vasopressin or oxytocin nonapeptide and in exon 2 encoding the central core of neurophysin. They are linked together in a tail to tail orientation separated by a short 3.5 kb intergenic sequence and are transcribed from opposite strands. Both genes have a single transcription initiation site downstream from a TATA-like sequence and a single polyadenylated transcript of about 760 bp for the vasopressin mRNA and about 700 bp for the oxytocin mRNA. © 1990.

引用

页码：319 / 324

页数：6

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